Club career
Danubio
Born in Toledo, Giménez made his professional debut for Danubio F.C. in the Uruguayan Primera División on 17 November 2012 (when the manager was Juan Ramón Carrasco) against River Plate in which he started and played the full 90 minutes as Danubio lost the match 2–0.
2013–2016
On 24 April 2013, it was confirmed that Giménez had signed a five-year deal with Spanish side Atlético Madrid, and would join the club in the pre-season of the 2013–14 season. On 14 September, Giménez made his Atleti – and La Liga – debut, starting in a 4–2 home win over UD Almería. It was his only appearance of a league-winning season. Giménez's appearances were initially limited by competition from compatriot Diego Godín, as well as Miranda and Toby Alderweireld.
In August 2014, Giménez won the Supercopa de España against rivals Real Madrid, though he did not leave the substitutes' bench in either game. He scored his first goal for the club on 6 December 2014, opening a 2–0 win away to Elche CF to move Atlético into second place. He played more often in 2014–15 due to Alderweireld's departure, and the club then sold Miranda to Inter Milan, with Giménez having achieved higher averages per game of tackles and interceptions than the Brazilian veteran. Giménez was a regular starter the following season, until losing his place to Stefan Savić for the last third of the campaign.
2016–2019
In July 2016, Giménez was naturalised as a citizen of Spain, thereby freeing up one of Atlético's three spots for players from outside the European Union. He struggled for appearances in 2016–17, due to injuries and the form of Godín, Savić and Lucas Hernandez. On 27 September 2017, he made his 100th appearance in a Champions League group 2–1 home loss to Chelsea, and was honoured with a plaque on the "Walk of Legends" at Atlético's new Metropolitano Stadium. His team won the UEFA Europa League, with him partnering Godín in central defence for the 3–0 win over Olympique de Marseille in the final on 16 May.
In June 2018, with 134 games to his name, Giménez signed a new five-year contract. Atlético won the 2018 UEFA Super Cup on 15 August, with Giménez playing as a substitute for Diego Costa in the last 10 minutes of extra time in a 4–2 win over Real Madrid in Tallinn. On 20 February 2019, he scored the opener in 2-0 home win against Italian champions Juventus to give Atlético the advantage in the first leg of the Round of 16 fixture in the UEFA Champions League.
2019–2026
Ahead of the 2019–20 season, after Godín's departure, manager Diego Simeone named Koke as Atlético captain, followed by goalkeeper Jan Oblak, then Giménez as third-captain. Atlético won the league in 2020–21, with Simeone, Giménez and Koke the only veterans of their previous triumph in 2014; Savić and Mario Hermoso were the preferred central defensive pairing.
In August 2021, on 216 appearances across all competitions, Giménez's contract was extended to 2025. On 6 August 2023, this was extended to 2028. He made his 300th appearance for the club on 16 December that year, coming on as a substitute for Çağlar Söyüncü in a 2–0 loss at Athletic Bilbao; he became the 31st player to reach the mark.
Loan to Deportivo A Coruña
On 1 September 2026, Giménez was loaned to Deportivo A Coruña also in the top tier, for one year.


